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Biology 201:      Genetics, Fall 2008

Instructor:          Dr. Ed Devlin

Website:           http://people.hsc.edu/faculty-staff/edwardd/edsweb01/index.htm

Office:               Gilmer 107, 6173, edevlin@hsc.edu

 Course Description

This course is designed to be an introduction to genetics, the science of heredity. It involves both classic Mendelian and modern molecular aspects of the study of inheritance. The material in this course is intended to build on the introduction to genetics you were exposed to in Biology 110. This course is important because a basic understanding of genetics is necessary to fully appreciate the workings of cells, organisms and how they change over time.

 It is a unique time to for a student to be embarking on the study of genetics. We have accumulated a critical mass of information about the structure of genes and how they function. This information is seeing practical applications in a number of disciplines from law enforcement to biomedical disciplines.

 I am maintaining some supporting materials for the course at my website under "Courses" and "Genetics" (http://people.hsc.edu/faculty-staff/edwardd/edsweb01/genetics.htm). At this site you can find copies of  syllabi, a sample test, problem sets, links and other information. This material call also be accessed through Blackboard. Genetics is a 200-level course and attendance of both lecture and lab are required. As per College policy, you can have up to three unexcused lecture absences, but no unexcused labs. The laboratory is considered a very important part of the course. You cannot pass the course if you have any unexcused lab absences.

Text:    

 There are many excellent genetics texts, unfortunately, many of them are designed for an upper division undergraduate course. We will be using a text this semester that is current and seems to be quite readable: Essential Genetics, A Genomics Perspective, Fouth Edition, 2006 by Hartl and Jones. The text is required for the course, in addition a lab manual for the lab will be provided.

 Grading/Honor Code:

 There will be four lecture exams and a cumulative final exam. The exams will be a combination of multiple-choice, short answer an essay in format. The laboratory portion of the course will be graded on the basis of your weekly lab reports as well as your oral and written presentation. I expect integrity as put forth in the Honor Code from all students on all their work in this course. Below is how the different aspects of the course are weighted to make up your final grade.

Lecture Exams                          60 %

Final Exam                    20 %

Laboratory                     20 %       

Total                             100 %

 For part of your lab grade, you will be required to write a short paper and give an oral, PowerPoint -based presentation of your paper topic. The paper will be on some aspect of genetic technology of interest to you that has been used in some practical way in agriculture, medicine, forensics, drug design or genetic testing. Your paper/presentation should explain the rational behind the technology, the technology itself and how it is used. We will be providing more information on the formatting of the paper/presentation in lab.


          

                                                  LECTURE SCHEDULE

 

TOPIC                                                                                                   READING ASSIGNMENT (CHAPTER)

                                                                                                            

                                                                                                              1. Introduction to Genetics                                              1

                                                                                                              2. Genetics and Evolution                                               1

                                                                                                              3. Rules of Inheritance                                                    2

                                                                                                              4. Segregation and Independent Assortment                     2

                                                                                                              5. Pedigree Analysis                                                      2

                                                                                                              6. Epistasis and Complementation                                  3

                                                                                                              7. DNA Packaging and the Cell Cycle                              3

                                                                                                              8. Mitosis and Meiosis                                                   3

                                                                                                              9. Sex Chromosomes                                                     3

                                                                                                              10. Exam I                                                                    --

                                                                                                              11. Sex Chromosomes Continued                                   3

                                                                                                              12. Linkage                                                                   4

                                                                                                              13. Recombination                                                         4

                                                                                                              14. Three-Point Crosses                                                 4           

                                                                                                              15. Examples of Three Point Crosses                              4

                                                                                                              16. Dosage Compensation                                              5

                                                                                                              17. Aneuploidy in Humans                                              5

                                                                                                              18. “Lady of Charleston”                                                  --

                                                                                                              19. Extranuclear Inheritance                                            14

                                                                                                              20. Exam II                                                                    --

                                                                                                              21. Hardy-Weinberg Equilibrium                                      14

                                                                                                              22. Role of Environment in Phenotypic Expression            15

                                                                                                              23. Covariance                                                               15

                                                                                                              24. Examples of Multifactorial Trait Analysis                     15

                                                                                                              25. Quantitative Traits Summary                                      15

                                                                                                              26. Cystic Fibrosis - Case Study II                                  --

                                                                                                              27. Building Blocks of DNA                                             6

                                                                                                              28. DNA Replication                                                       6

                                                                                                              29. The Genetic Code                                                    8

                                                                                                              30. Exam III                                                                   --

                                                                                                              31.  Eukaryote Gene Structure                                        8

                                                                                                              32. Transcription                                                            8

                                                                                                              33. Translation                                                               8

                                                                                                              34. Operons                                                                  9

                                                                                                              35. Transcription Factors in Eukaryotes                           9

                                                                                                              36. Transcript Processing                                               9

                                                                                                              37. Mutations                                                                12

                                                                                                              38. Repair Mechanisms                                                  12

                                                                                                              39.  “A Right to Her Genes” - Case Study III                     --

                                                                                                              40.  Cancer                                                                   13

                                                                                                              41. Exam IV                                                                  --

                                                                                                              42. Review                                

  

                                                          LABORATORY SCHEDULE

         Lab Number            Date                                      Topic

 

1.                     Sept 1                           The nature and methods of science

2.                     Sept 8                           Probability

3.                     Sept 15                         Yeast crosses

4.                     Sept 22                         Yeast crosses continued

5.                     Sept 29                         Drosophila dihybrid crosses

6.                     Oct 6                            Drosophila linkage mapping

7.                     Oct 13                          Finish work on Drosophila

            8.                     Oct 27                          Bioinfomatics

            9.                     Nov 3                            Standard Curves

            10.                    Nov 10                         Polymerase chain reaction (PCR)

            11.                    Nov 17                          Electrophoresis of PCR results

            12.                    Nov 24                          Case Study, Seeds of Dissension

            13.                    Dec 1                            Lab presentations

            14.                    Dec 8                            Lab presentations

  

Most labs are designed to fit into the scheduled lab period, but because we are using living organisms that take time to grow and reproduce, you will sometimes need to return to lab outside the scheduled lab period. This is unfortunate, but is the nature of the work done in the discipline. Some of the out-of-class work time will be offset by labs that are very short or may just require a few initial observations. The grade in the lab, which makes up 20% of your final grade in the course is made up of:

  

                        Weekly Lab Reports                               15%

                         Paper and Presentation                            5%

 

                                                                          Total   20% 

 

Lab reports on completed labs are to be turned in at the beginning of the next week's lab, late assignments will be penalized. These lab reports need not be overly elaborate, but must be typed and take the following format: 

                                                Purpose and Hypothesis

                                                Brief Methods

                                                Results and Discussion

                                                Conclusion and/or Answers to Questions